Deprenyl (selegiline) is devoid of
amphetamine-like behavioural effects in rats.ABSTRACT
Department of Pharmacology,
Semmelweis University of Medicine, Budapest, Hungary.
Acta Physiol Hung 1992;79(2):131-7
Central effects of high dose (-)deprenyl
(50-100 mg/kg sc) was compared to that of (+)deprenyl and (+/-)amphetamine
(AM). (+)Deprenyl and AM induced stereotyped behaviour, increased
spontaneous motility in smaller and decreased it in higher doses, inhibited
escape behaviour and shuttle-box avoidance. (-)Deprenyl failed to possess
any of these effects, providing further evidence that AM-type metabolites
have no share in the action of (-)deprenyl.